Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study - Institut Gustave Roussy Access content directly
Journal Articles International Journal of Cancer Year : 2023

Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study

Anthony Turpin
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My‐linh Tran-Minh
Simon Pernot
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Pascal Hammel
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Abstract

Pancreatic adenosquamous carcinoma (PASC) account for < 5% of pancreatic malignancies. The efficacy of modern chemotherapy regimens in patients with advanced PASC is unknown. Patients with advanced PASC from 2008 to 2021 were consecutively included in this retrospective multicenter study. Overall survival (OS) and progression-free survival (PFS) were evaluated by Kaplan-Meier method. Ninety-four PASC from 16 French centers were included (median age, 67.3 years; males, 56.4%; metastatic disease, 85.1%). The first-line treatment was chemotherapy for 79 patients (84.0%) (37 FOLFIRINOX (FX), 7 Gemcitabine-nab paclitaxel (GN) and 35 for all other regimen) or best supportive care (BSC) alone for 15 patients (16.0%). No significant difference was observed between FX and GN in terms of PFS (P = .67) or OS (P = .5). Modern regimens pooled together (FX and GN) as compared to all others chemotherapy regimens showed an improvement of overall response rate (39.5% and 9.7%, P = .002), PFS (median, 7.8 vs 4.7 months, P = .02) and OS (median, 12.7 vs 9.2 months, P = .35). This large study evaluating first-line treatment regimens in advanced PASC suggests that modern regimens as FX or GN may be preferable to all other chemotherapy regimens. These results deserve confirmation in prospective studies.

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Cancer
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hal-03969427 , version 1 (15-02-2023)

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Attribution - NonCommercial

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Marie Auvray Kuentz, Vincent Hautefeuille, Louis de Mestier, Clelia Coutzac, Thierry Lecomte, et al.. Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study. International Journal of Cancer, 2023, ⟨10.1002/ijc.34414⟩. ⟨hal-03969427⟩
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