Protein-protein interaction network inference with semi-supervised Output Kernel Regression

Abstract : In this work, we address the problem of protein-protein interaction network inference as a semi-supervised output kernel learning problem. Using the kernel trick in the output space allows one to reduce the problem of learning from pairs to learning a single variable function with values in a Hilbert space. We turn to the Reproducing Kernel Hilbert Space theory devoted to vector- valued functions, which provides us with a general framework for output kernel regression. In this framework, we propose a novel method which allows to extend Output Kernel Regression to semi-supervised learning. We study the relevance of this approach on transductive link prediction using artificial data and a protein-protein interaction network of S. Cerevisiae using a very low percentage of labeled data.