C. Chang and Z. Werb, The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis, Trends Cell Biol, vol.11, pp.37-43, 2001.

A. D. Luster, R. Alon, and U. H. Von-andrian, Immune cell migration in inflammation: present and future therapeutic targets, Nature Imm, vol.6, pp.1182-1190, 2005.

J. T. Parsons, A. R. Horwitz, and M. A. Schwartz, Cell adhesion: integrating cytoskeletal dynamics and cellular tension, Nat Rev Mol Cell Biol, vol.11, pp.633-643, 2010.

M. L. Gardel, I. C. Schneider, Y. Aratyn-schaus, and C. M. Waterman, Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration, Annu Rev Cell Dev Biol, vol.26, pp.3-4, 2010.

L. Clainche, C. Carlier, and M. , Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration, Physiol Rev, vol.88, pp.489-513, 2008.

T. Lammermann and M. Sixt, Mechanical modes of ',amoeboid' cell migration, Current Opinion in Cell Biology, vol.21, pp.636-644, 2009.

J. H. Iwasa and R. D. Mullins, Spatial and Temporal Relationships between Actin-Filament Nucleation, Capping, and Disassembly, Curr Biol, vol.17, pp.395-406, 2007.

T. M. Svitkina and G. G. Borisy, Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia, J Cell Bio, vol.145, pp.1009-1026, 1999.

C. K. Choi, M. Vicente-manzanares, J. Zareno, L. A. Whitmore, and A. Mogilner, Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner, Nat Cell Biol, vol.109, pp.14434-14439, 2008.

M. Vicente-manzanares, C. K. Choi, and A. R. Horwitz, Integrins in cell migration-the actin connection, J Cell Sci, vol.122, pp.199-206, 2009.

M. L. Gardel, B. Sabass, J. L. Danuser, G. Schwarz, and U. S. , Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed, J Cell Biol, vol.183, pp.999-1005, 2008.

N. S. Bryce, E. S. Clark, J. Leysath, J. D. Currie, and D. J. Webb, Cortactin Promotes Cell Motility by Enhancing Lamellipodial Persistence, Curr Biol, vol.15, pp.1276-1285, 2005.

S. L. Gupton, K. L. Anderson, T. P. Kole, R. S. Fischer, and A. Ponti, Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin, J Cell Biol, vol.168, pp.619-631, 2005.

D. Nardo, A. Cicchetti, G. Falet, H. Hartwig, J. H. Stossel et al., Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function, Proc Natl Acad Sci U S A, vol.102, pp.16263-16268, 2005.

S. M. Nicholson-dykstra and H. N. Higgs, Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes, Cell Motil Cytoskeleton, vol.65, pp.904-922, 2008.

C. Wu, S. Asokan, M. Berginski, E. Haynes, and N. Sharpless, Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis, Cell, vol.148, pp.973-987, 2012.

P. Suraneni, B. Rubinstein, J. R. Unruh, M. Durnin, and D. Hanein, The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration, J Cell Bio, vol.197, pp.239-251, 2012.

A. Diz-munoz, M. Krieg, M. Bergert, I. Ibarlucea-benitez, and D. J. Muller, Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment, PLoS Biol, vol.8, p.1000544, 2010.

O. T. Fackler and R. Grosse, Cell motility through plasma membrane blebbing, J Cell Bio, vol.181, pp.879-884, 2008.

G. T. Charras, M. Coughlin, T. J. Mitchison, and L. Mahadevan, Life and times of a cellular bleb, Biophys J, vol.94, pp.1836-1853, 2008.

G. Charras and E. Paluch, Blebs lead the way: how to migrate without lamellipodia, Nat Rev Mol Cell Biol, vol.9, pp.730-736, 2008.

R. Poincloux, O. Collin, F. Lizrraga, M. Romao, and M. Debray, Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel, Proc Natl Acad Sci U S A, vol.108, pp.1943-1948, 2011.

M. Bergert, S. D. Chandradoss, R. A. Desai, and E. Paluch, Cell mechanics control rapid transitions between blebs and lamellipodia during migration, Proc Natl Acad Sci U S A, vol.10, pp.14434-14439, 2012.

B. J. Nolen, N. Tomasevic, A. Russell, D. W. Pierce, and Z. Jia, Characterization of two classes of small molecule inhibitors of Arp2/3 complex, Nature, vol.460, pp.1031-1034, 2009.

Y. Aratyn-schaus and M. L. Gardel, Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension, Curr Biol, vol.20, pp.1145-1153, 2010.

B. Wehrle-haller, Assembly and disassembly of cell matrix adhesions, Curr Opin Cell Biol, vol.24, pp.569-581, 2012.

C. I. Lacayo, Z. Pincus, M. M. Vanduijn, C. A. Wilson, and D. A. Fletcher, Emergence of large-scale cell morphology and movement from local actin filament growth dynamics, PLoS Biol, vol.5, p.233, 2007.

S. A. Rizvi, E. M. Neidt, J. Cui, Z. Feiger, and C. T. Skau, Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly, Chem Biol, vol.16, pp.1158-1168, 2009.

P. W. Oakes, Y. Beckham, J. Stricker, and M. L. Gardel, Tension is required but not sufficient for focal adhesion maturation without a stress fiber template, J Cell Bio, vol.196, pp.363-374, 2012.

J. Dai and M. P. Sheetz, Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers, Biophys J, vol.68, pp.988-996, 1995.

R. Merkel, R. Simson, D. A. Simson, M. Hohenadl, and A. Boulbitch, A Micromechanic Study of Cell Polarity and Plasma Membrane Cell Body Coupling in Dictyostelium, Biophys J, vol.79, pp.707-719, 2000.

R. M. Hochmuth, Micropipette aspiration of living cells, J Biomechanics, vol.33, pp.15-22, 2000.

K. A. Demali, C. A. Barlow, and K. Burridge, Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion, J Cell Biol, vol.159, pp.881-891, 2002.

I. Thievessen, P. M. Thompson, S. Berlemont, K. M. Plevock, and S. V. Plotnikov, Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth, J Cell Bio, vol.202, pp.163-177, 2013.

C. Wu, E. M. Haynes, S. B. Asokan, J. M. Simon, and N. E. Sharpless, Loss of Arp2/3 induces an NF-kB-dependent, nonautonomous effect on chemotactic signaling, J Cell Bio, vol.203, pp.907-916, 2013.

J. Saarikangas, H. Zhao, and P. Lappalainen, Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides, Physiol Rev, vol.90, pp.259-289, 2010.

D. Raucher and M. P. Sheetz, Cell Spreading and Lamellipodial Extension Rate Is Regulated by Membrane Tension, J Cell Bio, vol.148, pp.127-136, 2000.

C. M. Laukaitis, D. J. Webb, K. Donais, and A. F. Horwitz, Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells, J Cell Biol, vol.153, pp.1427-1440, 2001.