Muscle function in A canine model of X-linked myotubular myopathy

Robert Grange (1) , Jon Doering , Erin Mitchell , Melanie Holder , Xuan Guan , Melissa Goddard (2) , Christopher Tegeler , Alan H. Beggs (3) , Martin K. Childers (4)

1 LAM - Laboratoire d'Astrophysique de Marseille
2 IMBI - Immunologie moléculaire et biothérapies innovantes
3 Genomics Program and Division of Genetics
4 Wake Forest University

We established a colony of dogs that harbor an X-linked MTM1 missense mutation.Muscle from affected male dogs exhibits reduction and altered localization of the MTM1 gene product, myotubularin, and provides a model analogous to X-linked myotubular myopathy (XLMTM).

Domains: Life Sciences [q-bio]

Robert Grange, Jon Doering, Erin Mitchell, Melanie Holder, Xuan Guan, et al.. Muscle function in A canine model of X-linked myotubular myopathy. Muscle & nerve. Supplement., 2012, 46 (4), pp.588-591. ⟨10.1002/mus.23463⟩. ⟨hal-02180879⟩