Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Inhibition of abasic site cleavage in bubble DNA by multifunctional protein YB-1

Abstract : Y-box binding protein 1 (YB-1) is widely known to participate in a multiple DNA and RNA processing events in the living cell. YB-1 is also regarded as a putative component of DNA repair. This possibility is supported by relocalization of YB-1 into the nucleus following genotoxic stress. Increased affinity of YB-1 for damaged DNA, especially in its singlestranded form, and its functional interaction with proteins responsible for the initiation of apurinic/apyrimidinic (AP) site repair, namely, AP endonuclease 1 and DNA glycosylase NEIL1, suggest that YB-1 could be involved in the repair of AP sites as a regulatory protein. Here we show that YB-1 has a significant inhibitory effect on the cleavage of AP sites located in single-stranded DNA and in DNA bubble structures. Such interference may be considered as a possible mechanismto prevent single-stranded intermediates of DNA replication, transcription and repair frombeing converted into highly genotoxic DNA strand breaks, thus allowing the cell to coordinate different DNA processing mechanisms.
Document type :
Journal articles
Complete list of metadata
Contributor : Olek Maciejak Connect in order to contact the contributor
Submitted on : Thursday, July 18, 2019 - 11:37:04 AM
Last modification on : Monday, September 27, 2021 - 11:19:44 AM

Links full text



Elizaveta Fomina, Pavel Pestryakov, Dmitry Kretov, Dmitry Zharkov, Lev Ovchinnikov, et al.. Inhibition of abasic site cleavage in bubble DNA by multifunctional protein YB-1. Journal of Molecular Recognition, Wiley, 2015, 28 (2), pp.117-123. ⟨10.1002/jmr.2435⟩. ⟨hal-02188084⟩



Record views