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Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP
Abstract : A significant fraction of mRNAs is known to be asso-ciated in the form of mRNPs with microtubules for active trans-port. However, little is known about the interaction betweenmRNPs and microtubules and most of previous works were fo-cused on molecular motor:microtubule interactions. Here, wehave identified, via high resolution atomic force microscopyimaging, a significant binding of mRNA to microtubules medi-ated by two major mRNP proteins, YB-1 and PABP. This inter-action with microtubules could be of critical importance foractive mRNP traffic and for mRNP granule formation. A similarrole may be fulfilled by other cationic mRNA partners.
https://hal-univ-evry.archives-ouvertes.fr/hal-02295333
Contributor : Olek Maciejak <>
Submitted on : Tuesday, September 24, 2019 - 10:34:24 AM
Last modification on : Monday, June 29, 2020 - 4:46:35 PM
Contributor : Olek Maciejak <>
Submitted on : Tuesday, September 24, 2019 - 10:34:24 AM
Last modification on : Monday, June 29, 2020 - 4:46:35 PM
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