Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP

Abstract : A significant fraction of mRNAs is known to be asso-ciated in the form of mRNPs with microtubules for active trans-port. However, little is known about the interaction betweenmRNPs and microtubules and most of previous works were fo-cused on molecular motor:microtubule interactions. Here, wehave identified, via high resolution atomic force microscopyimaging, a significant binding of mRNA to microtubules medi-ated by two major mRNP proteins, YB-1 and PABP. This inter-action with microtubules could be of critical importance foractive mRNP traffic and for mRNP granule formation. A similarrole may be fulfilled by other cationic mRNA partners.
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Konstantin Chernov, Patrick Curmi, Loic Hamon, Alain Mechulam, Lev Ovchinnikov, et al.. Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP. FEBS Letters, Wiley, 2008, 582 (19), pp.2875-2881. ⟨10.1016/j.febslet.2008.07.019⟩. ⟨hal-02295333⟩

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