J. C. Lindon and J. K. Nicholson, Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics, Annu Rev Anal Chem, vol.1, pp.45-69, 2008.

A. R. Fernie, R. N. Trethewey, A. J. Krotzky, and L. Willmitzer, Metabolite profiling: from diagnostics to systems biology, Nat Rev Mol Cell Biol, vol.5, pp.763-769, 2004.

W. B. Dunn, D. I. Broadhurst, H. J. Atherton, R. Goodacre, and J. L. Griffin, Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy, Chem Soc Rev, vol.40, pp.387-426, 2011.

N. Psychogios, D. D. Hau, J. Peng, A. C. Guo, R. Mandal et al., The human serum metabolome, PLoS One, vol.6, p.16957, 2011.

R. Goodacre, D. Broadhurst, A. K. Smilde, B. S. Kristal, D. Baker et al., Proposed minimum reporting standards for data analysis in metabolomics, Metabolomics, pp.231-241, 2007.

, The Human Metabolome Database

D. S. Wishart, D. Tzur, C. Knox, R. Eisner, A. C. Guo et al., HMDB: the Human Metabolome Database, Nucleic Acids Res, vol.35, pp.521-526, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01712873

J. Trygg, E. Holmes, and T. Lundstedt, Chemometrics in metabonomics, J Proteome Res, vol.6, pp.469-479, 2007.

W. B. Dunn, N. J. Bailey, and H. E. Johnson, Measuring the metabolome: current analytical technologies, Analyst, vol.130, pp.606-625, 2005.

E. Holmes, I. D. Wilson, and J. K. Nicholson, Metabolic phenotyping in health and disease, Cell, vol.134, pp.714-717, 2008.

K. Jungermann and T. Kietzmann, Oxygen: modulator of metabolic zonation and disease of the liver, Hepatology, vol.31, pp.255-260, 2000.

J. C. Lindon, H. C. Keun, T. M. Ebbels, J. M. Pearce, E. Holmes et al., The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements, Pharmacogenomics, vol.6, pp.691-699, 2005.

T. A. Clayton, D. Baker, J. C. Lindon, J. R. Everett, and J. K. Nicholson, Pharmacometabonomic identification of a significant hostmicrobiome metabolic interaction affecting human drug metabolism, Proc Natl Acad Sci, vol.106, pp.14728-14733, 2009.

J. H. Winnike, Z. Li, F. A. Wright, J. M. Macdonald, T. M. O'connell et al., Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans, Clin Pharmacol Ther, vol.88, pp.45-51, 2010.

V. Saxena, A. Gupta, N. Gowda, G. A. Saxena, R. Yachha et al., 1H NMR spectroscopy for the prediction of therapeutic outcome in patients with fulminant hepatic failure, NMR Biomed, vol.19, pp.521-526, 2006.

P. Ranjan, A. Gupta, S. Kumar, G. A. Gowda, A. Ranjan et al., Detection of new amino acid markers of liver trauma by proton nuclear magnetic resonance spectroscopy, Liver Int, vol.26, pp.703-707, 2006.

J. B. Wang, S. B. Pu, Y. Sun, Z. F. Li, M. Niu et al., Metabolomic Profiling of Autoimmune Hepatitis: The Diagnostic Utility of Nuclear Magnetic Resonance Spectroscopy, J Proteome Res, 2014.

D. Lavanchy, The global burden of hepatitis C, Liver Int, vol.29, issue.1, pp.74-81, 2009.

M. M. Godoy, E. P. Lopes, R. O. Silva, F. Hallwass, L. C. Koury et al., Hepatitis C virus infection diagnosis using metabonomics, J Viral Hepat, vol.17, pp.854-858, 2010.

R. Amathieu, P. Nahon, M. Triba, N. Bouchemal, J. C. Trinchet et al., Metabolomic approach by 1H NMR spectroscopy of serum for the assessment of chronic liver failure in patients with cirrhosis, J Proteome Res, vol.10, pp.3239-3245, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00609858

B. Martínez-granados, D. Monleón, M. C. Martínez-bisbal, R. J. Del-olmo, J. Lluch et al., Metabolite identification in human liver needle biopsies by high-resolution magic angle spinning 1H NMR spectroscopy, NMR Biomed, vol.19, pp.90-100, 2006.

B. Martínez-granados, J. M. Morales, J. M. Rodrigo, D. Olmo, J. Serra et al., Metabolic profile of chronic liver disease by NMR spectroscopy of human biopsies

, Int J Mol Med, vol.27, pp.111-117, 2011.

K. Yu, G. Sheng, J. Sheng, Y. Chen, W. Xu et al., A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis B virus, J Proteome Res, vol.6, pp.2413-2419, 2007.

S. Qi, Z. Tu, X. Ouyang, L. Wang, W. Peng et al., Comparison of the metabolic profiling of hepatitis B virus-infected cirrhosis and alcoholic cirrhosis patients by using (1) H NMR-based metabonomics, Hepatol Res, vol.42, pp.677-685, 2012.

S. W. Qi, Z. G. Tu, W. J. Peng, L. X. Wang, X. Ou-yang et al., ¹H NMR-based serum metabolic profiling in compensated and decompensated cirrhosis, World J Gastroenterol, vol.18, pp.285-290, 2012.

B. Jiménez, C. Montoliu, D. A. Macintyre, M. A. Serra, A. Wassel et al., Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance, J Proteome Res, vol.9, pp.5180-5187, 2010.

R. Amathieu, M. N. Triba, P. Nahon, N. Bouchemal, W. Kamoun et al., Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis, PLoS One, vol.9, p.89230, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02489938

H. Gao, Q. Lu, X. Liu, H. Cong, L. Zhao et al., Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis, Cancer Sci, vol.100, pp.782-785, 2009.

P. Nahon, R. Amathieu, M. N. Triba, N. Bouchemal, J. C. Nault et al., Identification of serum proton NMR metabolomic fingerprints associated with hepatocellular carcinoma in patients with alcoholic cirrhosis, Clin Cancer Res, vol.18, pp.6714-6722, 2012.
URL : https://hal.archives-ouvertes.fr/hal-02489955

M. I. Shariff, A. I. Gomaa, I. J. Cox, M. Patel, H. R. Williams et al., Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population: a validation study, J Proteome Res, vol.10, pp.1828-1836, 2011.

M. I. Shariff, N. G. Ladep, I. J. Cox, H. R. Williams, E. Okeke et al., Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population, J Proteome Res, vol.9, pp.1096-1103, 2010.

R. Soper, U. Himmelreich, D. Painter, R. L. Somorjai, C. L. Lean et al., Pathology of hepatocellular carcinoma and its precursors using proton magnetic resonance spectroscopy and a statistical classification strategy, Pathology, vol.34, pp.417-422, 2002.

H. Wen, S. S. Yoo, J. Kang, H. G. Kim, J. S. Park et al., A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer, J Hepatol, vol.52, pp.228-233, 2010.

N. J. Serkova, Y. Zhang, J. L. Coatney, L. Hunter, M. E. Wachs et al., Early detection of graft failure using the blood metabolic profile of a liver recipient, Transplantation, vol.83, pp.517-521, 2007.

H. V. Melendez, D. Ahmadi, H. G. Parkes, M. Rela, G. Murphy et al., Proton nuclear magnetic resonance analysis of hepatic bile from donors and recipients in human liver transplantation, Transplantation, vol.72, pp.855-860, 2001.

S. U. Munshi, S. Taneja, N. S. Bhavesh, J. Shastri, R. Aggarwal et al., Metabonomic analysis of hepatitis E patients shows deregulated metabolic cycles and abnormalities in amino acid metabolism, J Viral Hepat, vol.18, pp.591-602, 2011.

U. Andersson, J. Lindberg, S. Wang, R. Balasubramanian, M. Marcusson-ståhl et al., Schuppe-Koistinen I. A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran, Biomarkers, vol.14, pp.572-586, 2009.

A. W. Sharif, H. R. Williams, T. Lampejo, S. A. Khan, D. S. Bansi et al., Metabolic profiling of bile in cholangiocarcinoma using in vitro magnetic resonance spectroscopy, HPB (Oxford), vol.12, pp.396-402, 2010.

Y. Yang, C. Li, X. Nie, X. Feng, W. Chen et al., Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning 1H NMR spectroscopy in conjunction with multivariate data analysis, J Proteome Res, vol.6, pp.2605-2614, 2007.

J. F. Cobbold, J. H. Patel, R. D. Goldin, B. V. North, M. M. Crossey et al., Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study, J Hepatol, vol.52, pp.16-24, 2010.

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