Lung Stereotactic Arc Therapy in Mice Development of Radiation Pneumopathy and Influence of HIF-1α Endothelial Deletion

Keywords : Biological organs Irradiation Mammals Radiotherapy Tissue Gene expression levels Hypoxia inducible factor 1-alpha Ipsilateral lungs Local tumor control Methods and materials Radiation-induced Research platforms Radiation chlordane cre recombinase hypoxia inducible factor 1alpha vascular endothelial cadherin integrase animal tissue Article cell infiltration comparative study cone beam computed tomography controlled study endothelium follow up gene expression genotype lung disease lung edema major gene mouse neutrophil nonhuman priority journal quantitative analysis radiation dose radiation exposure radiation induced tissue damage radiation injury real time polymerase chain reaction stereotactic body radiation therapy tissue injury treatment planning adverse event diagnostic imaging disease model epithelial mesenchymal transition genetics intensity modulated radiation therapy lung alveolus lung fibrosis lung tumor metabolism pathology physiology procedures radiation pneumonia radiation response Animals Cone-Beam Computed Tomography Disease Models Animal Epithelial-Mesenchymal Transition Gene Deletion Hybridization Genetic Hypoxia-Inducible Factor 1 alpha Subunit Integrases Lung Lung Neoplasms Mice Organs at Risk Phenotype Pulmonary Alveoli Pulmonary Edema Pulmonary Fibrosis Radiation Dosage Radiation Pneumonitis Radiosurgery Intensity-Modulated Running Selective Breeding