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Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

Abstract : The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. In addition to its roles in RNA metabolism, FUS is implicated in the maintenance of DNA integrity. In this review, we examine the participation of FUS in major DNA repair pathways, focusing on DNA repair associated with poly(ADP-ribosyl)ation events and on howthe interaction of FUSwith poly(ADP-ribose)may orchestrate transient compartmentalisation ofDNAstrand breaks. Unravelling howprion-likeRNA-binding proteins control DNA repair pathways will deepen our understanding of the pathogenesis of some neurological diseases and cancer as well as provide the basis for the development of relevant innovative therapeutic technologies. This knowledgemay also extend the range of applications of poly(ADP-ribose) polymerase inhibitors to the treatment of neurodegenerative diseases related to RNA-binding proteins in the cell, e.g., amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
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https://hal-univ-evry.archives-ouvertes.fr/hal-02968942
Contributor : Olek Maciejak <>
Submitted on : Friday, October 16, 2020 - 11:19:25 AM
Last modification on : Thursday, October 22, 2020 - 9:50:37 AM

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Maria Sukhanova, Anastasia Singatulina, David Pastre, Olga Lavrik. Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩. ⟨hal-02968942⟩

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