Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

Benjamin Ducarouge (1, 2) , Anna-Rita Redavid (2) , Camille Victoor (2, 1) , Ruxanda Chira (2, 1) , Aurélien Fonseca (3) , Maëva Hervieu (2) , Roméo Bergé (2, 1) , Justine Lengrand (2, 1) , Pauline Vieugué (2) , David Neves (1) , Isabelle Goddard (2) , Mathieu Richaud (2) , Pierre-Alexandre Laval (2) , Nicolas Rama (2) , David Goldschneider (1) , Andrea Paradisi (2) , Nicolas Gourdin (2) , Sylvie Chabaud (3) , Isabelle Treilleux (3) , Nicolas Gadot (3) , Isabelle Ray-Coquard (3) , Stéphane Depil (1) , Didier Decaudin (4) , Fariba Némati (5) , Elisabetta Marangoni (4) , Eliane Mery-Lamarche (6) , Catherine Génestie (7, 8) , Séverine Tabone-Eglinger (3) , Mojgan Devouassoux-Shisheboran (9) , Kathryn Moore (10) , Benjamin Gibert (2) , Patrick Mehlen (2, 1) , Agnes Bernet (2, 1)

1 Netris Pharma
2 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
3 Centre Léon Bérard [Lyon]
4 Institut Curie [Paris]
5 Laboratoire Joliot Curie
6 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
7 IGR - Institut Gustave Roussy
8 Département de médecine oncologique [Gustave Roussy]
9 HCL - Hospices Civils de Lyon
10 NYU Grossman School of Medicine - New York University School of Medicine

Domaines: Cancer

Benjamin Ducarouge, Anna-Rita Redavid, Camille Victoor, Ruxanda Chira, Aurélien Fonseca, et al.. Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor. Cell Death and Differentiation, 2023, 30 (10), pp.2201-2212. ⟨10.1038/s41418-023-01209-x⟩. ⟨hal-04253805⟩