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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Databases Antibodies Disease maps Autoimmunity Rheumatoid Polyarthrite rhumatoïde Genotype Phenotype Biologie des systèmes Alleles Anti-Idiotypic Boolean simulations Boolean networks Gene Frequency Environment Animals Cohort Studies Single Nucleotide Genetic Predisposition to Disease Boolean models Adult Male Adolescent Odds Ratio Annotation standards Genetic Linkage Algerian population APOPTOSIS Europe Age of Onset CARD Signaling Adaptor Proteins Genetic Association Studies Linkage Disequilibrium Autoimmune thyroid diseases In silico simulations Receptors Humans Génétique Antirheumatic Agents Ankylosing Complex genetic disease HLA-DRB1 Logical modelling Non-Receptor Type 22 Binding Sites Antigen Presentation European Continental Ancestry Group Computational systems biology Association study Rheumatoid Factor Epitopes Aged Autoantibodies Protein Tyrosine Phosphatase Biological pathway Autoimmune thyroid disease Analysis Young Adult C-Type Biocuration Middle Aged Reproducibility Rheumatoid Arthritis Patient Female Systems biology POLYMORPHISM Genetic Autoantibody Production HLA-DRB1 Chains ASSOCIATION STUDY African Continental Ancestry Group Family Family Health Biomarkers Anti-citrullinated protein antibodies Rheumatoid arthritis Arthritis PTPN22 gene ATP Binding Cassette Transporter ABCB1 Age Factors Shared Epitope 80 and over Rheumatoid Arthritis France RHEUMATOID ARTHRITIS Autoimmune Diseases CASP7 GENE Biologie computationnelle des systèmes Algeria Genetics Haplotypes Network inference Case-Control Studies Ankylosing spondylitis Antigens HLA-DR Antigens Tunisia Polymorphism Risk Factors

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